H2N2V1, 1957, Analysis, bibRecord, 000126

Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia

Identifieur interne : 000126 ( 1957/Analysis ); précédent : 000125; suivant : 000127

Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia

Auteurs : Ville T. Peltola ; K. Gopal Murti [États-Unis] ; Jonathan A. Mccullers

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2005.

RBID : ISTEX:D587CC152DC4685067505883F679482ED1939AE2

Abstract

Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. Recombinant influenza viruses with neuraminidases from representative strains from the past 50 years were created and characterized. The specific level of their neuraminidase activity correlated with their ability to support secondary bacterial pneumonia. Recombinant viruses with neuraminidases from 1957 and 1997 influenza strains had the highest level of activity, whereas a virus with the neuraminidase from a 1968 strain had the lowest level of activity. The high level of activity of the neuraminidase from the 1957 strain, compared with that of other neuraminidases, more strongly supported the adherence of Streptococcus pneumoniae and the development of secondary bacterial pneumonia in a mouse model. These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary bacterial pneumonia and subsequent excess mortality

Url:

DOI: 10.1086/430954

Affiliations:

Links to Exploration step

ISTEX:D587CC152DC4685067505883F679482ED1939AE2

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia</title>
<author><name sortKey="Peltola, Ville T" sort="Peltola, Ville T" uniqKey="Peltola V" first="Ville T." last="Peltola">Ville T. Peltola</name>
</author>
<author><name sortKey="Murti, K Gopal" sort="Murti, K Gopal" uniqKey="Murti K" first="K. Gopal" last="Murti">K. Gopal Murti</name>
</author>
<author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D587CC152DC4685067505883F679482ED1939AE2</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1086/430954</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-XXR113JR-N/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001246</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001246</idno>
<idno type="wicri:Area/Istex/Curation">001246</idno>
<idno type="wicri:Area/Istex/Checkpoint">000498</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000498</idno>
<idno type="wicri:doubleKey">0022-1899:2005:Peltola V:influenza:virus:neuraminidase</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715995</idno>
<idno type="RBID">PMC:2715995</idno>
<idno type="wicri:Area/Pmc/Corpus">000533</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000533</idno>
<idno type="wicri:Area/Pmc/Curation">000533</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000533</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C23</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C23</idno>
<idno type="wicri:Area/Ncbi/Merge">000129</idno>
<idno type="wicri:Area/Ncbi/Curation">000129</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000129</idno>
<idno type="wicri:doubleKey">0022-1899:2005:Peltola V:the:influenza:virus</idno>
<idno type="wicri:Area/Main/Merge">001624</idno>
<idno type="wicri:Area/Main/Curation">001596</idno>
<idno type="wicri:Area/Main/Exploration">001596</idno>
<idno type="wicri:Area/1957/Extraction">000126</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia<ref type="fn" target="#fn1"></ref>
</title>
<author><name sortKey="Peltola, Ville T" sort="Peltola, Ville T" uniqKey="Peltola V" first="Ville T." last="Peltola">Ville T. Peltola</name>
<affiliation><wicri:noCountry code="no comma">Infectious Diseases and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Murti, K Gopal" sort="Murti, K Gopal" uniqKey="Murti K" first="K. Gopal" last="Murti">K. Gopal Murti</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Molecular Biotechnology, St. Jude Children’s Research Hospital, Memphis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
<affiliation></affiliation>
<affiliation><wicri:noCountry code="no comma">E-mail: jon.mccullers@stjude.org</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Journal of Infectious Diseases</title>
<title level="j" type="abbrev">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="2005-07-15">2005</date>
<biblScope unit="vol">192</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="249">249</biblScope>
<biblScope unit="page" to="257">257</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Secondary bacterial pneumonia is a common cause of death during influenza epidemics. We hypothesized that virus-specific factors could contribute to differences in annual excess mortality. Recombinant influenza viruses with neuraminidases from representative strains from the past 50 years were created and characterized. The specific level of their neuraminidase activity correlated with their ability to support secondary bacterial pneumonia. Recombinant viruses with neuraminidases from 1957 and 1997 influenza strains had the highest level of activity, whereas a virus with the neuraminidase from a 1968 strain had the lowest level of activity. The high level of activity of the neuraminidase from the 1957 strain, compared with that of other neuraminidases, more strongly supported the adherence of Streptococcus pneumoniae and the development of secondary bacterial pneumonia in a mouse model. These data lend support to our hypothesis that the influenza virus neuraminidase contributes to secondary bacterial pneumonia and subsequent excess mortality</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Tennessee</li>
</region>
</list>
<tree><noCountry><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name>
<name sortKey="Peltola, Ville T" sort="Peltola, Ville T" uniqKey="Peltola V" first="Ville T." last="Peltola">Ville T. Peltola</name>
</noCountry>
<country name="États-Unis"><region name="Tennessee"><name sortKey="Murti, K Gopal" sort="Murti, K Gopal" uniqKey="Murti K" first="K. Gopal" last="Murti">K. Gopal Murti</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000126 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000126 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    1957
   |étape=   Analysis
   |type=    RBID
   |clé=     ISTEX:D587CC152DC4685067505883F679482ED1939AE2
   |texte=   Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia

Influenza Virus Neuraminidase Contributes to Secondary Bacterial Pneumonia

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.